Selected Publications
Holt DJ*, DeTore NR*, Aideyan B, Utter L, Vinke LN, Johnson DS, Zimmerman J, Dokholyan KN, Burke A. Enhancing social functioning using multi-user, immersive virtual reality. Sci Rep. 2025 Jan 22
Clauss JA*, Foo CYS*, Leonard CJ, Dokholyan KN, Cather C, Holt DJ. Screening for psychotic experiences and psychotic disorders in general psychiatric settings: a systematic review and meta-analysis. Harv Rev Psych. (In Press)
Vinke, L.N., Avanaki, M., Jeffrey, C,. Harikumar, A., Mow, J.L., Tootell R.B.H., DeTore N.R., Holt, D.J., Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex. Mol Psychiatry. 2025 Feb 3.
Holt, D.J., DeTore, N.R., Aideyan, B., Utter, L., Vinke, L.N., Johnson, D.S., Zimmerman, J., Dokholyan, K.N., Burke, A., Enhancing social functioning using multi-user, immersive virtual reality. Sci Rep. 2025 Jan 22; 15, 2790.
DeTore NR, Balogun-Mwangi O, Eberlin ES, Dokholyan KN, Rizzo A, Holt DJ. An Artificial intelligence-based virtual human avatar application to assess the mental health of health care professionals: A Validation Study. Journal of Medical Extended Reality. 2024 Oct 1;1(1):215-26.
Babadi B, Dokholyan K, DeTore NR, Tootell RBH, Sussman RF, Zapetis SL, Holt DJ. Arousal responses to personal space intrusions in psychotic illness: A virtual reality study. Schizophr Res. 2024 Sep 20;274:158-170. PMID: 39305791. Epub 2024 Sep 20
Jacobs GR, Coleman MJ, Lewandowski KE, Pasternak O, Cetin-Karayumak S, Mesholam-Gately RI, Wojcik J, Kennedy L, Knyazhanskaya E, Reid B, Swago S, Lyons MG, Rizzoni E, John O, Carrington H, Kim N, Kotler E, Veale S, Haidar A, Prunier N, Haaf M, Levitt JJ, Seitz-Holland J, Rathi Y, Kubicki M, Keshavan MS, Holt DJ, Seidman LJ, Öngür D, Breier A, Bouix S, Shenton ME. An introduction to the human connectome project for early psychosis. Schizophr Bull. 2024 Jul 20;sbae123. PMID: 39036958. Epub 2024 Jul 20
Ward HB, Beermann A, Xie J, Yildiz G, Felix KM, Addington J, Bearden CE, Cadenhead K, Cannon TD, Cornblatt B, Keshavan M, Mathalon D, Perkins DO, Seidman L, Stone WS, Tsuang MT, Walker EF, Woods S, Coleman MJ, Bouix S, Holt DJ, Öngür D, Breier A, Shenton ME, Heckers S, Halko MA, Lewandowski KE, Brady RO Jr. Robust brain correlates of cognitive performance in psychosis and its prodrome. Biol Psychiatry. 2024 Jul 18;S0006-3223(24)01460. PMID: 39032726. Epub 2024 Jul 18
Deo AJ, Castro VM, Baker A, Carroll D, Gonzalez-Heydrich J, Henderson DC, Holt DJ, Hook K, Karmacharya R, Roffman JL, Madsen EM, Song E, Adams WG, Camacho L, Gasman S, Gibbs JS, Fortgang RG, Kennedy CJ, Lozinski G, Perez DC, Wilson M, Reis BY, Smoller JW. Validation of an ICD-code-based case definition for psychotic illness across three health systems. Schizophr Bull. 2024 May 10;sbae064. PMID: 38728421. https://doi.org/10.1093/schbul/sbae064. Epub 2024 May 10
Blokland GAM, Maleki N, Jovicich J, Mesholam-Gately RI , DeLisi LE, Turner JA, Shenton ME, Voineskos AN, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Lee J, Sim K, Lam M, de Zwarte SMC, Walton E, Kelly S, Picchioni MM, Bramon E, Makris N, David AS, Mondelli V, Reinders AATS, Oykhman E, Morris DW, Gill M, Corvin AP, Cahn W, Ho N, Liu J, Gollub RL, Manoach DS, Calhoun VD, Sponheim SR, Buka SL, Cherkerzian S, Thermenos HW, Dickie EW, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Keshavan MS , Petryshen TL, Del Re EC. MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume. Int J Clin Health Psychol. 2024;24(2):100458. PMID: 38623146. PMCID: PMC11017057. https://doi.org/10.1016/j.ijchp.2024.100458. Epub 2024 Apr 09
Deng W, Tuominen L, Sussman R, Leathem L, Vinke LN, Holt DJ. Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs. Sci Rep. 2024 Apr 8;14(1):8173. PMID: 38589562. PMCID: PMC11001942. https://doi.org/10.1038/s41598-024-57746-z. Epub 2024 Apr 08
Feola B, Beermann A, Manzanarez Felix K, Coleman M, Bouix S, Holt DJ, Lewandowski KE, Öngür D, Breier A, Shenton ME, Heckers S, Brady RO Jr, Blackford JU, Ward HB. Data-driven, connectome-wide analysis identifies psychosis-specific brain correlates of fear and anxiety. Mol Psychiatry. 2024 Mar 19. PMID: 38503924. https://doi.org/10.1038/s41380-024-02512-w. Epub 2024 Mar 19
Moussa-Tooks AB, Beermann A, Manzanarez Felix K, Coleman M, Bouix S, Holt DJ, Lewandowski KE, Öngür D, Breier A, Shenton ME, Heckers S, Walther S, Brady RO Jr, Ward HB. Isolation of distinct networks driving action and cognition in psychomotor processes. Biol Psychiatry. 2024 Mar 5;S0006-3223(24)01133. PMID: 38452884. https://doi.org/10.1016/j.biopsych.2024.02.1013. Epub 2024 Mar 05
Hughes DE, Kunitoki K*, Elyounssi S*, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL. Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development. Nat Neurosci. 2023 Jun;26(6):959-969. PMID: 37202553. PMCID: PMC7614744. https://doi.org/10.1038/s41593-023-01321-8. Epub 2023 May 18
Levitt JJ, Zhang F, Vangel M, Nestor PG, Rathi Y, Cetin-Karayumak S, Kubicki M, Coleman MJ, Lewandowski KE, Holt DJ, Keshavan M, Bouix S, Öngür D, Breier A, Shenton ME, O'Donnell LJ. The organization of frontostriatal brain wiring in non-affective early psychosis compared with healthy subjects using a novel diffusion imaging fiber cluster analysis. Mol Psychiatry. 2023 Jun;28(6):2301-2311. PMID: 37173451. https://doi.org/10.1038/s41380-023-02031-0. Epub 2023 May 12
Senay O, Seethaler M, Makris N, Yeterian E, Rushmore J, Cho KIK, Rizzoni E, Heller C, Pasternak O, Szczepankiewicz F, Westin CF, Losak J, Ustohal L, Tomandl J, Vojtisek L, Kudlicka P, Kikinis Z, Holt DJ, Lewandowski KE, Lizano P, Keshavan MS, Öngür D, Kasparek T, Breier A, Shenton ME, Seitz-Holland J, Kubicki M. A preliminary choroid plexus volumetric study in individuals with psychosis. Hum Brain Mapp. 2023 Apr 15;44(6):2465-2478. PMID: 36744628. PMCID: PMC10028672. https://doi.org/10.1002/hbm.26224. Epub 2023 Feb 06
Qi W, Marx J, Zingman M, Li Y, Petkova E, Blessing E, Ardekani B, Sakalli Kani A, Cather C, Freudenreich O, Holt DJ, Zhao J, Wang J, Goff DC. Hippocampal subfield volumes predict disengagement from maintenance treatment in first episode schizophrenia. Schizophr Bull. 2023 Jan 3;49(1):34-42. PMID: 36370124. PMCID: PMC9810017. https://doi.org/10.1093/schbul/sbac043
Clauss JA, Bhiku K, Burke A, Pimentel-Diaz Y, DeTore NR, Zapetis S, Zvonar V, Kritikos K, Canenguez KM, Cather C*, Holt DJ*. Development of a transdiagnostic, resilience-focused intervention for at-risk adolescents. J Ment Health. 2023 Jun;32(3):592-601. PMID: 36369940. PMCID: PMC10175511. https://doi.org/10.1080/09638237.2022.2140790. Epub 2022 Nov 12
Tootell RBH*, Nasiriavanaki Z*, Babadi B, Greve DN, Nasr S, Holt DJ. Interdigitated columnar representation of personal space and visual space in human parietal cortex. J Neurosci. 2022 Nov 30;42(48):9011-9029. PMID: 36198501. PMCID: PMC9732835. https://doi.org/10.1523/JNEUROSCI.0516-22.2022. Epub 2022 Oct 05
Eryilmaz H, Pax M, O'Neill AG, Vangel M, Diez I, Holt DJ, Camprodon JA, Sepulcre J, Roffman JL. Network hub centrality and working memory performance in schizophrenia. Schizophrenia (Heidelb). 2022 Sep 23;8(1):76. PMID: 36151201. PMCID: PMC9508261. https://doi.org/10.1038/s41537-022-00288-y. Epub 2022 Sep 23
Holt DJ, Zapetis SL, Babadi B, Zimmerman J, Tootell RBH. Personal space increases during the COVID-19 pandemic in response to real and virtual humans. Front Psychol. 2022;13:952998. PMID: 36186356. PMCID: PMC9515568. https://doi.org/10.3389/fpsyg.2022.952998. Epub 2022 Sep 14
Zapetis SL, Nasiriavanaki Z, Luther L, Holt DJ. Neural correlates of variation in personal space and social functioning in schizophrenia and healthy individuals. Schizophr Bull. 2022 Sep 1;48(5):1075-1084. PMID: 35661903. PMCID: PMC9434426. https://doi.org/10.1093/schbul/sbac052
Kim GW, Farabaugh AH, Vetterman R, Holmes A, Nyer M, Nasiriavanaki Z, Fava M, Holt DJ. Diminished frontal pole size and functional connectivity in young adults with high suicidality. J Affect Disord. 2022 Aug 1;310:484-492.
Zimmerman J, DeTore NR, Deng W, Burke A, Nyer M, Holt DJ. Worsening of psychotic experiences in college students during the COVID-19 pandemic. Schizophr Res. 2022 Jun 27:S0920-9964(22)00255-9. Epub ahead of print.
Zapetis SL, Nasiriavanaki Z, Luther L, Holt DJ. Neural Correlates of Variation in Personal Space and Social Functioning in Schizophrenia and Healthy Individuals. Schizophr Bull. 2022 Jun 5:sbac052.
Kim GW, Farabaugh AH, Vetterman R, Holmes A, Nyer M, Nasiriavanaki Z, Fava M, Holt DJ. Diminished frontal pole size and functional connectivity in young adults with high suicidality. J Affect Disord. 2022 Aug 1;310:484-492. PMID: 35427718. https://doi.org/10.1016/j.jad.2022.04.069. Epub 2022 Apr 13
Wright AC, Cather C, Mueser KT, Farabaugh A, Terechina O, Fava M, Holt DJ. Relationships among subclinical psychotic symptoms in young adults over time. Psychiatry Res. 2022 May 10;314:114617.
DeTore NR, Luther L, Deng W, Zimmerman J, Leathem L, Burke AS, Nyer MB, Holt DJ. Efficacy of a transdiagnostic, prevention-focused program for at-risk young adults: a waitlist-controlled trial. Psychol Med. 2022 Mar 1:1-10.
Di Biase MA, Geaghan MP, Reay WR, Seidlitz J, Weickert CS, Pébay A, Green MJ, Quidé Y, Atkins JR, Coleman MJ, Bouix S, Knyazhanskaya EE, Lyall AE, Pasternak O, Kubicki M, Rathi Y, Visco A, Gaunnac M, Lv J, Mesholam-Gately RI, Lewandowski KE, Holt DJ, Keshavan MS, Pantelis C, Öngür D, Breier A, Cairns MJ, Shenton ME, Zalesky A. Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia. Mol Psychiatry. 2022 Apr;27(4):2052-2060. PMID: 35145230. PMCID: PMC9126812. https://doi.org/10.1038/s41380-022-01460-7. Epub 2022 Feb 10
Tootell RBH, Zapetis SL, Babadi B, Nasiriavanaki Z, Hughes DE, Mueser K, Otto M, Pace-Schott E, Holt DJ. Psychological and physiological evidence for an initial 'Rough Sketch' calculation of personal space. Sci Rep. 2021 Oct 25;11(1):20960.
Webler RD, Berg H, Fhong K, Tuominen L, Holt DJ, Morey RA, Lange I, Burton PC, Fullana MA, Radua J, Lissek S. The neurobiology of human fear generalization: meta-analysis and working neural model. Neurosci Biobehav Rev. 2021 Sep;128:421-436.
Wright AC, Cather C, Farabaugh A, Terechina O, Pedrelli P, Nyer M, Fava M, Holt DJ. Relationship between cannabis use and psychotic experiences in college students. Schizophr Res. 2021 May;231:198-204.
Nasiriavanaki Z, Barbour T, Farabaugh AH, Fava M, Holmes AJ, Tootell RBH, Holt DJ. Anxious attachment is associated with heightened responsivity of a parietofrontal cortical network that monitors peri-personal space. Neuroimage Clin. 2021;30:102585.
Wang D, Peng X, Pelletier-Baldelli A, Orlov N, Farabaugh A, Nasr S, Eryilmaz H, Fava M, Holmes AJ, Roffman JL, Liu H, Holt DJ. Altered temporal, but intact spatial, features of transient network dynamics in psychosis. Mol Psychiatry. 2021 Jun;26(6):2493-2503.
Burke, A. S., Shapero, B. G., Pelletier-Baldelli, A., Deng, W. Y., Nyer, M. B., Leathem, L., ... & Holt, D. J. (2020). Rationale, Methods, Feasibility, and Preliminary Outcomes of a Transdiagnostic Prevention Program for At-Risk College Students. Frontiers in Psychiatry, 10, 1030.
Barbour, T., Holmes, A. J., Farabaugh, A. H., DeCross, S. N., Coombs, G., Boeke, E. A., ... & Holt, D. J. (2020). Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(2), 194-202.
Pelletier-Baldelli, A., & Holt, D. J. (2020). Are Negative Symptoms Merely the “Real World” Consequences of Deficits in Social Cognition? Schizophrenia Bulletin, 46(2), 236-241.
DeCross, S. N., Farabaugh, A. H., Holmes, A. J., Ward, M., Boeke, E. A., Wolthusen, R. P., ... & Holt, D. J. (2020). Increased amygdala-visual cortex connectivity in youth with persecutory ideation. Psychological medicine, 50(2), 273-283.
Tuominen, L., Boeke, E., DeCross, S., Wolthusen, R. R., Nasr, S., Milad, M., ... & Holt, D. (2019). The relationship of perceptual discrimination to neural mechanisms of fear generalization. NeuroImage.
Shapero, B. G., Farabaugh, A., Terechina, O., DeCross, S., Cheung, J. C., Fava, M., & Holt, D. J. (2019). Understanding the effects of emotional reactivity on depression and suicidal thoughts and behaviors: Moderating effects of childhood adversity and resilience. Journal of affective disorders, 245, 419-427.
Wolthusen RPF, Coombs III G, Boeke EA, Ehrlich S, DeCross SN, Nasr S, Holt DJ. Correlation between levels of delusional beliefs and perfusion of the hippocampus and an associated network in a non–help-seeking population. Biological Psychiatry CCNI, 2018.
Ho NF, Iglesias JE, Sum MY, Kuswanto CN, Sitoh YY, De Souza J, Hon Z, Fischl B, Roffman JL, Zhou J, Sim K, Holt DJ. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Mol Psych. 2016.
Holt DJ, Boeke EA, Coombs G 3rd, DeCross SN, Cassidy BS, Stufflebeam S, Rauch SL, Tootell RBH. Abnormalities in personal space and parietal-frontal function in schizophrenia. Neuroimage Clin 2015; 9: 233-43.
Mueller S, Wang D, Pan R, Holt DJ, Liu H. Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia. JAMA Psych. 2015; 72: 552-560.
Holt DJ, Boeke EA, Wolthusen R, Nasr S, Milad MR, Tootell RBH. A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds. Front Hum Neurosci. 2014; 8: 624.
Brent BK, Seidman LJ, Coombs G, Keshevan MS, Moran JM, Holt DJ. Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions. Schiz Res. 2014; 157: 292-298.
Holt DJ, Cassidy BS, Yue X, Rauch SL, Boeke EA, Nasr S, Tootell RBH, Coombs III G. Neural correlates of personal space intrusion. J Neurosci. 2014; 34:4123-4134.
Brent BK, Coombs G, Keshevan MS, Seidman LJ, Moran JM, Holt DJ. Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection. Soc Cog Aff Neurosci. 2014; 9: 273-282.
Linnman C, Coombs G, Goff DC, Holt DJ. Lack of insula reactivity to aversive stimuli in schizophrenia. Schiz Res 2013; 143: 150-157.
Holt DJ, Coombs G, Zeidan MA, Goff DC, Milad MR. Failure of neural responses to safety cues in schizophrenia. Arch Gen Psych 2012; 69: 893-903.
Holt DJ, Cassidy BS, Andrews-Hanna JR, Lee SM, Goff DC, Gabrieli JD, Moran JM. An anterior-to-posterior shift in midline cortical activity during self-reflection in schizophrenia. Biol Psych. 2011; 69: 415-423.
Holt DJ, Lakshmanan B, Freudenreich O, Goff DC, Rauch SL, Kuperberg GR. Dysfunction of a cortical midline structure during emotional appraisals in schizophrenia. Schiz Bull 2011; 37: 164-176.
Holt DJ, Lynn SK, Kuperberg GR. Neurophysiological correlates of comprehending emotional meaning in context. J Cog Neurosci 2009; 11: 2245-2262.